Matthew Brown is a recent graduate of the University of Florida with a Bachelors of Science in Biochemistry & Molecular Biology. He joined the Brusko Lab in the summer of 2019 as a first-year undergraduate student to study the autoimmune response involving the destruction of pancreatic beta-cells which leads to Type 1 Diabetes (T1D). Matthew’s current work focuses on developing Treg adoptive cellular therapy & monoclonal antibody treatment strategies, as well as using genome-editing to evaluate the roles of T1D candidate genes such as CD226 and SIRPG in disease progression.

Publications

• Brown ME, Peters LD, Hanbali SR, Arnoletti JM, Sachs LK, Nguyen KQ, Carpenter EB, Seay HR, Fuhrman CA, Posgai AL, Shapiro MR, and Brusko TM (2022) Human CD4⁺CD25⁺CD226^– Tregs Demonstrate Increased Purity, Lineage Stability, and Suppressive Capacity Versus CD4⁺CD25⁺CD127^lo/- Tregs for Adoptive Cell Therapy. Front. Immunol. 13:873560. doi: 10.3389/fimmu.2022.873560

• Sharp RC*, Brown ME*, Shapiro MR, Posgai AL and Brusko TM (2021) The Immunoregulatory Role of the Signal Regulatory Protein Family and CD47 Signaling Pathway in Type 1 Diabetes. Front. Immunol. 12:739048. doi: 10.3389/fimmu.2021.739048

Presentations

• Brown ME, Sachs LK, Arnoletti JM, Nguyen KQ, Lee JJ, Lahde CC, Kern EJ, Peters LD, Shapiro MR, Brusko TM.  Human CD4⁺CD25⁺ Regulatory T Cells Deficient of CD226 Demonstrate Increased Purity and Lineage Stability Following Ex Vivo Expansion for Adoptive Treg Therapies. Oral Abstract and Poster presented at: Federation of Clinical Immunology Societies (FOCiS) 2022 Annual Meeting; 2022 Jun 21-24; San Fransisco, CA. (Poster of Merit Award Received)
• Sharp RC, Brown ME, Peters LD, Brusko TM. The signal regulatory protein gamma (SIRPγ) signaling constrains naïve CD8⁺ T cell activation with T1D risk associated polymorphisms leading to augmented T cell activation. Conference Paper prepared for: American Association of Immunologists Annual Meeting; 2022 May 6-10; Portland, OR.
• Brown ME, Arnoletti JM, Sachs LK, Nguyen KQ, Lee JJ, Brusko TM. CD226_^– Human Regulatory T Cells Exhibit Increased Stability Compared to Conventionally Sorted Populations. Poster presented at: 18th Congress of the Immunology of Diabetes Society (IDS); 2021 Nov 1-4; Virtual. (Outstanding Abstract Award Received)
• Brown ME, Hanbali SR, Gomez Rodriguez LM, Arnoletti JM, Carpenter EB, Brusko TM. Human CD4⁺CD25⁺CD226^– Regulatory T Cells Demonstrate High Purity and Lineage Stability Following In Vitro Expansion for Adoptive Cell Therapy. Poster presented at: 81st Scientific Sessions of the American Diabetes Association (ADA); 2021 Jun 25-29; Virtual.
• Sharp RC, Brown ME, Brusko TM. Modeling the SIRPγ and CD47 Pathway in Type 1 Diabetes Pathogenesis. Poster presented at: 2020 Annual Meeting of the Human Islet Research Network (HIRN); 2020 Sep 30 – Oct 02; Virtual.

Fellowships & Awards

• UF College of Medicine – 2021 University Scholar
• UF College of Medicine – 2020 University Scholar
• UF Center for Undergraduate Research – 2020 Emerging Scholar

Contact

Lab: (352) 273-9300

Email: matthewbrown@ufl.edu