Matthew Brown is a recent graduate of the University of Florida with a Bachelors of Science in Biochemistry & Molecular Biology. He joined the Brusko Lab in the summer of 2019 as a first-year undergraduate student to study the autoimmune response involving the destruction of pancreatic beta-cells leading to Type 1 Diabetes (T1D). Matthew’s current work focuses on developing Treg adoptive cellular therapy, deliverable biologic treatment strategies, as well as using genome-editing to evaluate the roles of T1D candidate genes in disease pathogenesis.
Publications
- Thirawatananond P*, Brown ME*, Sachs LK, Arnoletti JM, Yeh WI, Posgai AL, Shapiro MR, Chen YG, Brusko TM. (2023). Deletion of CD226 in Foxp3+ T cells Reduces Diabetes Incidence in Non-Obese Diabetic Mice by Improving Regulatory T Cell Stability and Function. Diabetes. doi: 10.1101/2022.06.02.494443,
- Shapiro MR, Peters LD, Brown ME, Cabello-Kindelan C, Posgai AL, Bayer AL, Brusko TM. (2023). Insulin-like Growth Factor-1 Synergizes with IL-2 to Induce Homeostatic Proliferation of Regulatory T Cells. Journal of Immunology. doi: 10.4049/jimmunol.2200651
- Peters LD, Yeh WI, Arnoletti JM, Brown ME, Posgai AL, Mathews CE, and Brusko TM. (2023). Modeling Cell-Mediated Immunity in Human Type 1 Diabetes by Engineering Autoreactive CD8+ T cells. Front. Immunol. 14:1142648. doi: 10.3389/fimmu.2023.1142648
- Brown ME, Peters LD, Hanbali SR, Arnoletti JM, Sachs LK, Nguyen KQ, Carpenter EB, Seay HR, Fuhrman CA, Posgai AL, Shapiro MR, and Brusko TM. (2022). Human CD4+CD25+CD226– Tregs Demonstrate Increased Purity, Lineage Stability, and Suppressive Capacity Versus CD4+CD25+CD127lo/- Tregs for Adoptive Cell Therapy. Front. Immunol. 13:873560. doi: 10.3389/fimmu.2022.873560
- Sharp RC*, Brown ME*, Shapiro MR, Posgai AL and Brusko TM. (2021). The Immunoregulatory Role of the Signal Regulatory Protein Family and CD47 Signaling Pathway in Type 1 Diabetes. Front. Immunol. 12:739048. doi: 10.3389/fimmu.2021.739048
Presentations
- Brown ME, Thirawatananond P, Kern EJ, Vijay S, Sachs LK, Nguyen KQ, Lahde CC, Shah AA, Shapiro MR, Brusko TM. Antibody Blockade of CD226 Decreases Diabetes Incidence in the NOD Mouse by Augmenting Treg Suppressive Capacity & Diminishing T Cell Cytotoxicity. Poster presented at: 19th Congress of the Immunology of Diabetes Society (IDS); 2023 May 23-27; Paris, France.
- Brown ME, Sachs LK, Arnoletti JM, Nguyen KQ, Lee JJ, Lahde CC, Kern EJ, Peters LD, Shapiro MR, Brusko TM. Human CD4+CD25+ Regulatory T Cells Deficient of CD226 Demonstrate Increased Purity and Lineage Stability Following Ex Vivo Expansion for Adoptive Treg Therapies. Oral Abstract and Poster presented at: Federation of Clinical Immunology Societies (FOCiS) 2022 Annual Meeting; 2022 Jun 21-24; San Fransisco, CA. (Poster of Merit Award Received)
- Sharp RC, Brown ME, Peters LD, Brusko TM. The signal regulatory protein gamma (SIRPγ) signaling constrains naïve CD8+ T cell activation with T1D risk associated polymorphisms leading to augmented T cell activation. Conference Paper prepared for: American Association of Immunologists Annual Meeting; 2022 May 6-10; Portland, OR.
- Brown ME, Arnoletti JM, Sachs LK, Nguyen KQ, Lee JJ, Brusko TM. CD226– Human Regulatory T Cells Exhibit Increased Stability Compared to Conventionally Sorted Populations. Poster presented at: 18th Congress of the Immunology of Diabetes Society (IDS); 2021 Nov 1-4; Virtual. (Outstanding Abstract Award Received)
- Brown ME, Hanbali SR, Gomez Rodriguez LM, Arnoletti JM, Carpenter EB, Brusko TM. Human CD4+CD25+CD226– Regulatory T Cells Demonstrate High Purity and Lineage Stability Following In Vitro Expansion for Adoptive Cell Therapy. Poster presented at: 81st Scientific Sessions of the American Diabetes Association (ADA); 2021 Jun 25-29; Virtual.
- Sharp RC, Brown ME, Brusko TM. Modeling the SIRPγ and CD47 Pathway in Type 1 Diabetes Pathogenesis. Poster presented at: 2020 Annual Meeting of the Human Islet Research Network (HIRN); 2020 Sep 30 – Oct 02; Virtual.
Fellowships & Awards
- UF College of Medicine – 2021 University Scholar
- UF College of Medicine – 2020 University Scholar
- UF Center for Undergraduate Research – 2020 Emerging Scholar
Contact
Lab: (352) 273-9300
Email: matthewbrown@ufl.edu