Must Reads
Relevant to the Brusko Lab's Research

1. Understanding the drivers of MHC restriction of T cell receptors (La Gruta, 2018)
2. Application of a Genetic Risk Score to Racially Diverse T1D Populations Demonstrates the Need for Diversity in Risk-Modeling (Perry, 2018)
3. Expansion of Human Tregs from Cryopreserved Umbilical Cord Blood for GMP-Compliant Autologous ACT Therapy (Seay, 2016)
4. Tissue distribution and clonal diversity of the T and B cell repertoire in type 1 diabetes (Seay, 2016)
5. Immunogenetics of type 1 diabetes – A comprehensive review (Noble, 2015)
6. Type 1 diabetes immunotherapy using polyclonal regulatory T cells (Bluestone, 2015)
7. Current Concepts on the Pathogenesis of Type 1 Diabetes—Considerations for Attempts to Prevent and Reverse the Disease (Atkinson, 2015)
8. Type 1 Diabetes at a Crossroads! (Cefalu, 2015)
9. Type 1 diabetes (Atkinson, 2014)
10. The Juvenile Diabetes Research Foundation Network for Pancreatic Organ Donors with Diabetes (nPOD) Program: goals, operational model and emerging findings (Pugliese, 2014)
11. Enterovirus Infection and Type 1 Diabetes: Closing in on a Link? (Rodriguez-Calvo, 2015)
12. Type 1 Diabetes: Etiology, Immunology, and Therapeutic Strategies (Van Belle, 2011)
13. Type 1 diabetes and gut microbiota: Friend or foe? (Hu, 2015)
14. Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients (Coppieters, 2012)
15. Genetics of Type 1 Diabetes (Noble, 2012)
16. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes (Barrett, 2009)
17. The diagnosis of insulitis in human type 1 diabetes (Campbell-Thompson, 2013)
18. Human regulatory T cells: role in autoimmune disease and therapeutic opportunities (Brusko, 2008)
19. Islet Transplantation in Seven Patients with Type 1 Diabetes Mellitus Using a Glucocorticoid-Free Immunosuppressive Regimen (Shapiro, 2000)
20. Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research (2010, Kilkenny et al).

Autoreactivity of islet-infiltrating T cells in donors with T1D

1. Avidity and Bystander Suppressive Capacity of Human Regulatory T Cells Expressing De Novo Autoreactive T-Cell Receptors in T1D (Yeh, 2017)
2. Ueber die Beziehung der Langerhans’schen Inseln des Pankreas zum Diabetes mellitus (On the relationship of the Langerhans islands of the pancreas to the diabetes mellitus (Schmidt, 1902)
3. Insulitis in early juvenile diabetes (LeCompte, 1958)
4. Pathologic anatomy of the pancreas in juvenile diabetes mellitus (Gepts, 1965)

Human ImmunoPhenotyping Consortium

1. Standardizing Flow Cytometry Immunophenotyping Analysis from the Human ImmunoPhenotyping Consortium (Finak et al, 2016)
2. Standardizing immunophenotyping for the Human Immunology Project (Maecker et el, 2012)