JCI insight
Responders to low-dose ATG induce CD4 T cell exhaustion in type 1 diabetes
JCI Insight. 2023 Jul 11:e161812. doi: 10.1172/jci.insight.161812. Epub ahead of print. PMID: 37432736.
Authors: Jacobsen LM, Diggins K, Blanchfield L, McNichols JA, Perry DJ, Brant J, Dong X, Bacher R, Gersuk VH, Schatz DA, Atkinson MA, Mathews CE, Haller MJ, Long SA, Linsley PS, Brusko TM.
Frontiers in immunology
Modeling cell-mediated immunity in human type 1 diabetes by engineering autoreactive CD8+ T cells
Front Immunol. 2023 May 30;14:1142648. doi: 10.3389/fimmu.2023.1142648. PMID: 37325626; PMCID: PMC10262917.
Authors: Peters LD, Yeh WI, Arnoletti JM, Brown ME, Posgai AL, Mathews CE, Brusko TM.
FRONTIERS IN IMMUNOLOGY
Human CD4 + CD25 + CD226 – Tregs Demonstrate Increased Purity, Lineage Stability, and Suppressive Capacity Versus CD4 + CD25 + CD127 lo/- Tregs for Adoptive Cell Therapy
Front Immunol. 2022 May 26;13:873560. doi: 10.3389/fimmu.2022.873560. PMID: 35693814; PMCID: PMC9178079.
Authors:
Brown ME, Peters LD, Hanbali SR, Arnoletti JM, Sachs LK, Nguyen KQ, Carpenter EB, Seay HR, Fuhrman CA, Posgai AL, Shapiro MR, Brusko TM.
Frontiers in Immunology
The Immunoregulatory Role of the Signal Regulatory Protein Family and CD47 Signaling Pathway in Type 1 Diabetes REVIEW
Front Immunol. 2021 Sep 16;12:739048. doi: 10.3389/fimmu.2021.739048. PMID: 34603322; PMCID: PMC8481641.
Authors:
Sharp RC, Brown ME, Shapiro MR, Posgai AL, Brusko TM.
Protein Tyrosine Phosphatase Nonreceptor type 22 (PTPN22)
Perry DJ, Peters LD, Lakshmi PS, Zhang L, Han Z, Wasserfall CH, Mathews CE, Atkinson MA, Brusko TM. Overexpression of the PTPN22 Autoimmune Risk Variant LYP-620W Fails to Restrain Human CD4+ T Cell Activation. J Immunol. 2021 Aug 1;207(3):849-859. doi: 10.4049/jimmunol.2000708. Epub 2021 Jul 23.
CD226 (DNAM-1) rs763361
Shapiro MR, Yeh WI, Longfield JR, Gallagher J, Infante CM, Wellford S, Posgai AL, Atkinson MA, Campbell-Thompson M, Lieberman SM, Serreze DV, Geurts AM, Chen YG, Brusko TM. CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation. Front Immunol. 2020 Sep 4;11:2180. doi: 10.3389/fimmu.2020.02180.
Perry DJ, Titov AA, Sobel ES, Brusko TM, Morel L. Immunophenotyping reveals distinct subgroups of lupus patients based on their activated T cell subsets. Clin Immunol. 2020 Dec;221:108602. doi: 10.1016/j.clim.2020.108602. Epub 2020 Sep 29.
