Dr. Perry specializes in immune function and how its dysregulation can result in autoimmunity. His interests at the UF Diabetes Institute (UFDI) are in understanding how genetics and metabolism may affect lymphocyte function, and how they can be manipulated to ameliorate disease. Essential to this is the identification of biomarkers of pre-clinical disease progression and therapeutic responses. Hence, Dr. Perry has undertaken a discovery effort that involves comprehensive immunophenotyping and genotyping in a cohort of type 1 diabetes patients, relatives and controls. These efforts were the impetus for an Immune Monitoring Core, which he Co-Directs, and now offers services for immunophenotyping, genotyping, single-cell sequencing (transcriptome, antigen receptors, epigenome), immunoassays, and more. As the UFDI cohort has grows, he aims to link specific genetic risks and altered immune function to various diabetes endotypes, thus elucidating specific etiological pathways for intervention. In doing so, he is also establishing circulating immune cell reference ranges that will benefit the entire research community.
Publications
- Shapiro MR, Foster TP, Perry DJ, Rosenfeld RG, Dauber A, McNichols JA, Muir A, Hwa V, Brusko TM, Jacobsen LM. A Novel Mutation in Insulin-Like Growth Factor-1 Receptor (c.641-2A>G) Is Associated with Impaired Growth, Hypoglycemia, and Modified Immune Phenotypes. Horm Res Paediatr. 2020;93(5):322-334. doi: 10.1159/000510764. Epub 2020 Oct 28. PMID: 33113547.
- Dean, Joseph W; Peters, Leeana D; Fuhrman, Christopher A; Seay, Howard R; Posgai, Amanda L; Stimpson, Scott E; Brusko, Maigan A; Perry, Daniel J; Yeh, Wen-I; Newby, Brittney N; Haller, Michael J; Muir, Andrew B; Atkinson, Mark A; Mathews, Clayton E; Brusko, Todd M. (Mar 2020) Innate inflammation drives NK cell activation to impair Treg activity. Journal of autoimmunity. 108 :102417
- Motwani K, Peters LD, Vliegen WH, El-Sayed AG, Seay HR, Lopez MC, Baker HV, Posgai AL, Brusko MA, Perry DJ, Bacher R, Larkin J, Haller MJ, Brusko TM. Human Regulatory T Cells From Umbilical Cord Blood Display Increased Repertoire Diversity and Lineage Stability Relative to Adult Peripheral Blood. Front Immunol. 2020 Apr 15;11:611. doi: 10.3389/fimmu.2020.00611. PMID: 32351504; PMCID: PMC7174770.
- Beam CA, Wasserfall C, Woodwyk A, Akers M, Rauch H, Blok T, Mason P, Vos D, Perry D, Brusko T, Peakman M, Atkinson M. 2020. Synchronization of the Normal Human Peripheral Immune System: A Comprehensive Circadian Systems Immunology Analysis. Sci Rep. 10(1):672 . doi: 10.1038/s41598-019-56951-5.
- Perry DJ, Wasserfall CH, Oram RA, Williams MD, Posgai A, Muir AB, Haller MJ, Schatz DA, Wallet MA, Mathews CE, Atkinson MA, Brusko TM. 2018. “Application of a Genetic Risk Score to Racially Diverse Type 1 Diabetes Populations Demonstrates the Need for Diversity in Risk-Modeling“. Sci Rep. 8(1):4529.
- Jacobsen LM, Newby BN, Perry DJ, Posgai AL, Haller MJ, Brusko TM. 2018. “Immune Mechanisms and Pathways Targeted in Type 1 Diabetes“. Curr Diab Rep. 30;18(10):90. doi: 10.1007/s11892-018-1066-5.
- Chen J, Chernatynskaya AV, Li JW, Kimbrell MR, Cassidy RJ, Perry DJ, Muir AB, Atkinson MA, Brusko TM, Mathews CE. 2017. “T cells display mitochondria hyperpolarization in human type 1 diabetes“. Sci Rep. 7(1):10835.
- Marcial GE, Ford AL, Haller MJ, Gezan SA, Harrison NA, Cai D, Meyer JL, Perry DJ, Atkinson MA, Wasserfall CH, Garrett T, Gonzalez CF, Brusko TM, Dahl WJ, Lorca GL. 2017. “Lactobacillus johnsonii N6.2 Modulates the Host Immune Responses: A Double-Blind, Randomized Trial in Healthy Adults“. Front Immunol. 12;8:655.
- Lowe JR, Perry DJ, Salama AKS, Mathews CM, Moss LG, Hanks BA. 2016. “Genetic risk analysis of a patient with fulminant autoimmune type 1 diabetes mellitus secondary to combination ipilimumab and nivolumab immunotherapy“. J Immunother Cancer. 4:89.
- Haller MJ, Gitelman SE, Gottlieb PA, Michels AW, Perry DJ, Schultz AR, Hulme MA, Shuster JJ, Zou B, Wasserfall CH, Posgai A, Mathews CE, Brusko TM, Atkinson MA, Schatz DA. 2016. “Antithymocyte Globulin Plus G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes“. Diabetes 65(12): 3765-3775.
- Fuhrman CA, Yeh WI, Seay HR, Saikumar Lakshmi P, Chopra G, Zhang L, Perry DJ, McClymont SA, Yadav M, Lopez MC, Baker HV, Zhang Y, Li Y, Whitley M, von Schack D, Atkinson MA, Bluestone JA, Brusko TM. 2015. Divergent Phenotypes of Human Regulatory T Cells Expressing the Receptors TIGIT and CD226. J Immunol. 195(1):145-55.
- Yiming Yin, Seung-Chul Choi, Zhiwei Xu, Daniel J. Perry, Howard R. Seay, Byron P. Croker, Eric S. Sobel, Todd M. Brusko and Laurence Morel. “Normalization of CD4+ T cell metabolism reverses lupus” Science Translational Medicine. 2015 Feb 11;7(274):274ra18. doi: 10.1126/scitranslmed.aaa0835. PMID: 25673763
- Thompson JA, Perry D, Brusko TM. Autologous Regulatory T Cells for the Treatment of Type 1 Diabetes. Curr Diab Rep. 2012 Jul 28. PubMed PMID: 22843491.
- Perry DJ, Yin Y, Telarico T, Baker HV, Dozmorov I, Perl A, Morel L. Murine lupus susceptibility locus Sle1c2 mediates CD4+ T cell activation and maps to estrogen-related receptor γ. J Immunol. 2012 Jul 15;189(2):793-803. Epub 2012 Jun 18. PMID: 22711888
- Perry D, Peck AB, Carcamo WC, Morel L, Nguyen CQ. The current concept of T (h) 17 cells and their expanding role in systemic lupus erythematosus. Arthritis. 2011;2011:810649. Epub 2011 Mar 22.
- Xu Z, Potula HH, Vallurupalli A, Perry D, Baker H, Croker BP, Dozmorov I, Morel L. Cyclin-dependent kinase inhibitor Cdkn2c regulates B cell homeostasis and function in the NZM2410-derived murine lupus susceptibility locus Sle2c1. J Immunol. 2011 Jun 15;186(12):6673-82. Epub 2011 May 4. PubMed PMID: 21543644.
- Perry D, Sang A, Yin Y, Zheng YY, Morel L. Murine models of systemic lupus erythematosus. J Biomed Biotechnol. 2011;2011:271694. Epub 2011 Feb 14. Review. PubMed PMID: 21403825; PubMed Central PMCID: PMC3042628.
- Rahman ZS, Niu H, Perry D, Wakeland E, Manser T, Morel L. Expression of the autoimmune Fcgr2b NZW allele fails to be upregulated in germinal center B cells and is associated with increased IgG production. Genes Immun. 2007 Oct;8(7):604-12. Epub 2007 Aug 23. PubMed PMID: 17713556.
- Chen Y, Perry D, Boackle SA, Sobel ES, Molina H, Croker BP, Morel L. Several genes contribute to the production of autoreactive B and T cells in the murine lupus susceptibility locus Sle1c. J Immunol. 2005 Jul 15;175(2):1080-9. PubMed PMID: 16002709.