Type 1 Diabetes is an autoimmune disease that can start as early as six months of age and can lead to a lifetime of struggle dealing with the burdens of a chronic condition.  Our laboratory is committed to understanding why disease develops I those at risk, as well as developing novel therapies to halt and/or reverse the disease after onset. We are proud to both lead and take part in a number of team science efforts leading to a cure.

Lab news


Robert Sharp, PhD
University of Florida
Consortium: CHIB
Project: The SIRP:CD47 Signaling
Pathway in Pancreatic b-Cell Survival

HIRN 2021 news letter

IDS 2021 (Nov. 1 2021 – Nov, 4, 2021)

IDS 2021 Outstanding Abstract Awardees: Leeana Peters, Matthew Brown

Leeana Peters
Abstract Title
Single cell transcriptomic and epigenetic analysis of pancreatic lymph node tissues in T1D

Matthew Brown
Abstract Title
CD226- Human Regulatory T Cells Exhibit Increased Lineage Stability Compared to Conventionally Sorted Populations

Recent publications

Frontiers in Immunology

The Immunoregulatory Role of the Signal Regulatory Protein Family and CD47 Signaling Pathway in Type 1 Diabetes
REVIEW article
Front. Immunol., 16 September 2021 |

Authors: Robert C Sharp, PhD, Matthew E Brown Melanie R Shapiro, PhD, Amanda L Posgai, PhD, Todd M Brusko, PhD.
PMID: 34603322; PMCID: PMC8481641

Robert's review on Frontiers

New “Pancreatic Islet on a Chip” System Will…

Category: Feature

University of Florida researchers will use a new $5 million grant to develop a “pancreatic islet on a chip” — a platform that will allow them…

Islet on a Chip

Human Atlas of Neonatal Development and Early…

Category: Feature

Human Atlas of Neonatal Development and Early Life-Immunity (HANDEL-I) The early life events that influence immune system development have…


Helmsley Grant to UFDI to Study Immune Repertoire…

Category: Feature

University of Florida and Kings College London have secured a $3.7 million grant funded by Adaptive Biotechnologies and the Leona M. and Harry B…


T1D news

August 29, 2019

Pancreas on a chip

Beta-cell transplantation

pancreas on a chip

International Clinical Centers

Type 1 Diabetes TrialNet

The University of Florida (UF) is one of twenty-five Type 1 Diabetes TrialNet International Clinical Centers at the forefront of type 1 diabetes research. Led by Desmond Schatz, MD, the TrialNet team at UF is dedicated to preventing type 1 diabetes and stopping disease progression by preserving insulin production before and after diagnosis.

Biomedical Sciences Building