THE URGENCY OF NOW

Type 1 Diabetes is an autoimmune disease that can start as early as six months of age and can lead to a lifetime of struggle dealing with the burdens of a chronic condition.  Our laboratory is committed to understanding why disease develops I those at risk, as well as developing novel therapies to halt and/or reverse the disease after onset. We are proud to both lead and take part in a number of team science efforts leading to a cure.

Lab news

FOCIS 2022

Poster of Distinction Awards

Puchong Thirawatananond
Selective CD226 Knockout on Regulatory T cells Reduces Diabetes in Female NOD Mice
Matt Brown
Human CD4+CD25+Regulatory T Cells Deficient of CD226 Demonstrate Increased Purity and Lineage Stability Following Ex Vivo Expansion for Adoptive Treg Therapy

FOCIS_2022_MATT_PUCHONG

FOCIS 2022

Oral Presentations

Melanie Shapiro
Autoimmunity Risk Loci Tagged to CIITA and MHC Class II Impact CD8+ T Cell and Monocyte HLA-DR Expression
Matt Brown
Human CD4+CD25+Regulatory T Cells Deficient of CD226 Demonstrate Increased Purity and Lineage Stability Following Ex Vivo Expansion for Adoptive Treg Therapy

Melanie_FOCIS_2022

FOCIS 2022 Poster Presentations


Leeana Peters
Engineering Optimized Autoreactive T cells for the Study of Type 1 Diabetes Pathogenesis

Miguel Medina-Serpas
Integrating spatial transcriptomics and single-cell RNA sequencing to spatially characterize human lymphatic tissue

2022 Graduates with Honor Thesis

Lindsey Sachs
Matt Brown
Juan Martin Arnoletti

graduation pic_matt_martin_lindsey

New “Pancreatic Islet on a Chip” System Will…

Category: Feature

University of Florida researchers will use a new $5 million grant to develop a “pancreatic islet on a chip” — a platform that will allow them…

Islet on a Chip

Human Atlas of Neonatal Development and Early…

Category: Feature

Human Atlas of Neonatal Development and Early Life-Immunity (HANDEL-I) The early life events that influence immune system development have…

HANDEL-I

Helmsley Grant to UFDI to Study Immune Repertoire…

Category: Feature

University of Florida and Kings College London have secured a $3.7 million grant funded by Adaptive Biotechnologies and the Leona M. and Harry B…

DNA

T1D news

International Clinical Centers

Type 1 Diabetes TrialNet

The University of Florida (UF) is one of twenty-five Type 1 Diabetes TrialNet International Clinical Centers at the forefront of type 1 diabetes research. Led by Desmond Schatz, MD, the TrialNet team at UF is dedicated to preventing type 1 diabetes and stopping disease progression by preserving insulin production before and after diagnosis.

Biomedical Sciences Building