Keshav Motwani is a senior at UF majoring in math with minors in computer science and health disparities in society. He works on applying machine learning and bioinformatic approaches to T-cell receptor repertoires with a goal of developing classification tools to help with the diagnosis of type 1 diabetes and understanding the sequence-level motifs that are associated with type 1 diabetes.
Abstracts
- The T cell receptor CDR3β contains sequence motifs that predict disease state in nPOD samples – Oral presentation and poster presentation at 2018 nPOD Annual Meeting
Fellowships
- UF College of Medicine – 2019 University Scholar
- Barry M. Goldwater Scholarship & Excellence in Education Foundation – 2020 Scholar
Publications
- Motwani, K., Peters, L. D., Vliegen, W. H., El-Sayed, A. G., Seay, H. R., Lopez, M. C., … Brusko, T. M. (2020). Human Regulatory T Cells From Umbilical Cord Blood Display Increased Repertoire Diversity and Lineage Stability Relative to Adult Peripheral Blood. Frontiers in Immunology, 11. DOI: 10.3389/fimmu.2020.00611
- Emmi-Leena Ihantola, Henna Ilmonen, Anssi Kailaanmäki, Marja Rytkönen-Nissinen, Aurélien Azam, Bernard Maillère, Cecilia S. Lindestam Arlehamn, Alessandro Sette, Keshav Motwani, Howard R. Seay, Todd M. Brusko, Mikael Knip, Riitta Veijola, Jorma Toppari, Jorma Ilonen and Tuure Kinnunen. (Mar 2020) Characterization of Proinsulin T Cell Epitopes Restricted by Type 1 Diabetes–Associated HLA Class II Molecules. J Immunol. DOI: https://doi.org/10.4049/jimmunol.1901079.
- Khosravi-Maharlooei, M., Obradovic, A., Misra, A., Motwani, K., Holzl, M., Seay, H. R., DeWolf, S., Nauman, G., Danzl, N., Li, H., Ho, S. H., Winchester, R., Shen, Y., Brusko, T. M., & Sykes, M. (2019). Crossreactive public TCR sequences undergo positive selection in the human thymic repertoire. The Journal of clinical investigation, 129(6), 2446–2462. https://doi.org/10.1172/JCI124358