Melanie Shapiro, PhD


Melanie earned her Bachelor of Science Degree specialized in Cell Biology & Molecular Genetics from the University of Maryland in May 2015.

Melanie joined Dr. Todd Brusko’s laboratory as a graduate student in the Interdisciplinary Biomedical Sciences Program and completed her PhD in May 2020.

She is investigating the role of CD226 in the development of T1D in the non-obese diabetic mouse via impacts on central and peripheral tolerance. Melanie is also working in collaboration with the Atkinson lab to evaluate how insulin like growth factors modulate immune function and pancreatic growth in human subjects at risk for type 1 diabetes. She was awarded a predoctoral individual NRSA F31 from the NIDDK in 2018 to study “Roles of the Insulin-like Growth Factor Axis in Pre-Type 1 Diabetes Immune Regulation”.


  • Shapiro MR, Foster TP, Perry DJ, Rosenfeld RG, Dauber A, McNichols JA, Muir A,Hwa V, Brusko TM, Jacobsen LM. A Novel Mutation in Insulin-Like Growth Factor-1 Receptor (c.641-2A>G) Is Associated with Impaired Growth, Hypoglycemia, and Modified Immune Phenotypes. Horm Res Paediatr. In revision.
  • Shapiro MR, Yeh W, Longfield JR, Gallagher J, Infante CM, Wellford S, Posgai AL, Atkinson MA, Campbell-Thompson M, Lieberman SM, Serreze DV, Geurts AM, Chen Y, Brusko TM. CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation. Front Immunol. 2020 Jun. Submitted.
  • Melanie R. Shapiro, Clive H. Wasserfall, Sean M. McGrail, Amanda L. Posgai, Rhonda Bacher, Andrew Muir, Michael J. Haller, Desmond A. Schatz, Johnna D. Wesley, Matthias von Herrath, William A. Hagopian, Cate Speake, Mark A. Atkinson, Todd M. Brusko. (2019). Insulin-Like Growth Factor Dysregulation Both Preceding and Following Type 1 Diabetes Diagnosis. Diabetes. pii: db190942.
  • Shapiro, Melanie R., Atkinson, Mark A., Brusko, Todd M. (2019). Pleiotropic roles of the insulin-like growth factor axis in type 1 diabetes.  Current Opinion in Endocrinology, Diabetes and Obesity. 26(4): 188-194.  doi: 10.1097/MED.0000000000000484.
  • Futch, Hunter & McFarland, Karen & Moore, Brenda & Kuhn, M. & Giasson, Benoit & Ladd, Thomas & Scott, Karen & Shapiro, Melanie & Nosacka, Rachel & Goodwin, Marshall & Ran, Yong & Cruz, Pedro & Ryu, Daniel & Croft, Cara & Levites, Yona & Janus, Christopher & Chakrabarty, Paramita & Judge, Andrew & Brusko, Todd. (2019). An anti-CRF antibody suppresses the HPA axis and reverses stress-induced phenotypes. The Journal of Experimental Medicine. 216. jem.20190430. 10.1084/jem.20190430.
  • Graves CL, Li J, LaPato M, Shapiro MR, Glover SC, Wallet MA, Wallet SM. Intestinal Epithelial Cell Regulation of Adaptive Immune Dysfunction in Human Type 1 Diabetes. Front Immunol. 2017 Jan 10;7:679. doi: 10.3389/fimmu.2016.00679. eCollection 2016. PubMed PMID: 28119693; PubMed Central PMCID: PMC5222791. 
  • Seeley-Fallen MK, Liu LJ, Shapiro MR, Onabajo OO, Palaniyandi S, Zhu X, Tan TH, Upadhyaya A, Song W. Actin-binding protein 1 links B-cell antigen receptors to negative signaling pathways. Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9881-6. doi: 10.1073/pnas.1321971111. Epub 2014 Jun 23. PubMed PMID: 24958882; PubMed Central PMCID: PMC4103327.