Wen-I Yeh, PhD
Research Assistant Scientist


WYThe research interest of Dr. Yeh is focused on the regulation and function of immune populations during autoimmune diseases. Dr. Yeh received her doctoral degree at University of Alabama at Birmingham focusing the mechanisms of how CD4 T cells induce multiple sclerosis under the mentorship of Dr. Laurie Harrington. Her research in the Brusko Lab focuses on how the immune dysregulation leads to type 1 diabetes development in order to develop therapeutic interventions. She is particularly interested in T cells pathogenesis as how T cell receptor and co-stimulatory signaling pathways shaping autoreactive T cells. Furthermore, Dr. Yeh uses both lentivirus and CRISPR/Cas9 genome editing technology to correct defects or reinforce tolerance to prevent or reverse disease progression.


Email: wiyeh@ufl.edu


Publications

  • Wen-I Yeh, Howard R. Seay, Brittney Newby, Amanda L. Posgai, Filipa Botelho Moniz, Aaron Michels, Clayton E. Mathews, Jeffrey A. Bluestone, Todd M. Brusko. Avidity and Bystander Suppressive Capacity of Human Regulatory T Cells Expressing De Novo Autoreactive T-Cell Receptors in Type 1 Diabetes. Frontiers in Immunology, 2017. DOI: https://doi.org/10.3389/fimmu.2017.01313
  • Fuhrman CA, Wen-I Yeh, Seay HR, Saikumar Lakshmi P, Chopra G, Zhang L, Perry DJ, McClymont SA, Yadav M, Lopez MC, Baker HV, Zhang Y, Li Y, Whitley M, von Schack D, Atkinson MA, Bluestone JA, Brusko TM. Divergent Phenotypes of Human Regulatory T Cells Expressing the Receptors TIGIT and CD226. J Immunol. 2015 Jul 1;195(1):145-55. doi: 10.4049/jimmunol.1402381. Epub 2015 May 20. PubMed PMID: 25994968; PubMed Central PMCID: PMC4475416.
  • Wen-I Yeh, McWilliams IL, Harrington LE. IFN╬│ inhibits Th17 differentiation and function via Tbet-dependent and Tbet-independent mechanisms. J Neuroimmunol. 2014 Feb 15;267(1-2):20-7. doi: 10.1016/j.jneuroim.2013.12.001. Epub 2013 Dec 12. PubMed PMID: 24369297; PubMed Central PMCID: PMC4363997.
  • Beurel E, Kaidanovich-Beilin O, Wen-I Yeh, Song L, Palomo V, Michalek SM, Woodgett JR, Harrington LE, Eldar-Finkelman H, Martinez A, Jope RS. Regulation of Th1 cells and experimental autoimmune encephalomyelitis by glycogen synthase kinase-3. J Immunol. 2013 May 15;190(10):5000-11. doi: 10.4049/jimmunol.1203057. Epub 2013 Apr 19. PubMed PMID: 23606540; PubMed Central PMCID: PMC3660233.
  • Qin H, Wen-I Yeh, De Sarno P, Holdbrooks AT, Liu Y, Muldowney MT, Reynolds SL, Yanagisawa LL, Fox TH 3rd, Park K, Harrington LE, Raman C, Benveniste EN. Signal transducer and activator of transcription-3/suppressor of cytokine signaling-3 (STAT3/SOCS3) axis in myeloid cells regulates neuroinflammation. Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):5004-9. doi: 10.1073/pnas.1117218109. Epub 2012 Mar 12. PubMed PMID: 22411837; PubMed Central PMCID: PMC3323949.
  • Wen-I Yeh, McWilliams IL, Harrington LE. Autoreactive Tbet-positive CD4 T cells develop independent of classic Th1 cytokine signaling during experimental autoimmune encephalomyelitis. J Immunol. 2011 Nov 15;187(10):4998-5006. doi: 10.4049/jimmunol.1100031. Epub 2011 Oct 7. PubMed PMID: 21984703; PubMed Central PMCID: PMC3709433.
  • Beurel E, Wen-I Yeh, Michalek SM, Harrington LE, Jope RS. Glycogen synthase kinase-3 is an early determinant in the differentiation of pathogenic Th17 cells. J Immunol. 2011 Feb 1;186(3):1391-8. doi: 10.4049/jimmunol.1003511. Epub 2010 Dec 29. PubMed PMID: 21191064; PubMed Central PMCID: PMC3125578.
  • Agbottah E, Wen-I Yeh, Berro R, Klase Z, Pedati C, Kehn-Hall K, Wu W, Kashanchi F. Two specific drugs, BMS-345541 and purvalanol A induce apoptosis of HTLV-1 infected cells through inhibition of the NF-kappaB and cell cycle pathways. AIDS Res Ther. 2008 Jun 10;5:12. doi: 10.1186/1742-6405-5-12. PubMed PMID: 18544167; PubMed Central PMCID: PMC2483717.
  • Lo SS, Lin SC, Wu CW, Chen JH, Wen-I Yeh, Chung MY, Lui WY. Heme oxygenase-1 gene promoter polymorphism is associated with risk of gastric adenocarcinoma and lymphovascular tumor invasion. Ann Surg Oncol. 2007 Aug;14(8):2250-6. Epub 2007 May 23. PubMed PMID: 17520317.
  • Kehn K, Berro R, Alhaj A, Bottazzi ME, Wen-I Yeh, Klase Z, Van Duyne R, Fu S, Kashanchi F. Functional consequences of cyclin D1/BRCA1 interaction in breast cancer cells. Oncogene. 2007 Aug 2;26(35):5060-9. Epub 2007 Mar 5. PubMed PMID: 17334399.
  • Lin SC, Liu CJ, Wen-I Yeh, Lui MT, Chang KW, Chang CS. Functional polymorphism in NFKB1 promoter is related to the risks of oral squamous cell carcinoma occurring on older male areca (betel) chewers. Cancer Lett. 2006 Nov 8;243(1):47-54. Epub 2006 Jan 4. PubMed PMID: 16387424.
  • Chang KW, Lee TC, Wen-I Yeh, Chung MY, Liu CJ, Chi LY, Lin SC. Polymorphism in heme oxygenase-1 (HO-1) promoter is related to the risk of oral squamous cell carcinoma occurring on male areca chewers. Br J Cancer. 2004 Oct 18;91(8):1551-5. PubMed PMID: 15365571; PubMed Central PMCID: PMC2409944.