Puchong is an MD/PhD student who joined the Brusko lab in 2019. He graduated from Johns Hopkins with a major in Molecular and Cellular Biology. Before starting medical school, he worked as a technician for Sandra B. Gabelli to solve 3D protein structures through X-ray crystallography. One of his structures, an HLA presenting a neoantigen peptide, inspired him to pursue research in immunology and its modulation through immunotherapy.
Currently, Puchong is studying the use of gene editing to improve the safety and efficacy of adoptive cell therapy in T1D and other autoimmune diseases.
NIH Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral MD/PhD Fellowship (F30) “Generation of Islet Specific T Follicular Regulatory Like Cells for Autologous Cell Therapy of Type 1 Diabetes.” 2021.
Japp AS, Meng W, Rosenfeld AM, Perry DJ, Thirawatananond P, Bacher RL, Liu C, Gardner JS; HPAP Consortium, Atkinson MA, Kaestner KH, Brusko TM, Naji A, Luning Prak ET, Betts MR. TCR+/BCR+ dual-expressing cells and their associated public BCR clonotype are not enriched in type 1 diabetes. Cell. 2021 Feb 4;184(3):827-839.e14. doi: 10.1016/j.cell.2020.11.035. PMID: 33545036; PMCID: PMC8016147.
Shapiro MR, Thirawatananond P, Peters L, Sharp RC, Ogundare S, Posgai AL, Perry DJ, Brusko TM. De-coding genetic risk variants in type 1 diabetes. Immunol Cell Biol. 2021 Jan 22. doi: 10.1111/imcb.12438. Epub ahead of print. PMID: 33483996.
Thirawatananond P, McPherson RL, Malhi J, Nathan S, Lambrecht MJ, Brichacek M, Hergenrother PJ, Leung AKL, Gabelli SB. Structural analyses of NudT16-ADP-ribose complexes direct rational design of mutants with improved processing of poly(ADP-ribosyl)ated proteins. Sci Rep. 2019 Apr 11;9(1):5940. doi: 10.1038/s41598-019-39491-w. PMID: 30976021; PMCID: PMC6459841.
Lab: (352) 273-9300