Melanie joined the Brusko lab as a graduate student in the Interdisciplinary Biomedical Sciences Program in March 2016 after graduating with a degree in Cell Biology & Molecular Genetics from the University of Maryland. She is investigating the role of CD226 in the development of T1D in the non-obese diabetic mouse via impacts on central and peripheral tolerance. Melanie is also working in collaboration with the Atkinson lab to evaluate how insulin like growth factors modulate immune function and pancreatic growth in human subjects at risk for type 1 diabetes. She was awarded a predoctoral individual NRSA F31 from the NIDDK in 2018 to study “Roles of the Insulin-like Growth Factor Axis in Pre-Type 1 Diabetes Immune Regulation”.
- Graves CL, Li J, LaPato M, Shapiro MR, Glover SC, Wallet MA, Wallet SM. Intestinal Epithelial Cell Regulation of Adaptive Immune Dysfunction in Human Type 1 Diabetes. Front Immunol. 2017 Jan 10;7:679. doi: 10.3389/fimmu.2016.00679. eCollection 2016. PubMed PMID: 28119693; PubMed Central PMCID: PMC5222791.
- Seeley-Fallen MK, Liu LJ, Shapiro MR, Onabajo OO, Palaniyandi S, Zhu X, Tan TH, Upadhyaya A, Song W. Actin-binding protein 1 links B-cell antigen receptors to negative signaling pathways. Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9881-6. doi: 10.1073/pnas.1321971111. Epub 2014 Jun 23. PubMed PMID: 24958882; PubMed Central PMCID: PMC4103327.