Daniel J. Perry, PhD: Postdoctoral Fellow
Dr. Perry’s interest is in understanding the intricacies of immune function and how its dysregulation can result in autoimmunity. He earned his doctoral degree at the University of Florida, where he studied the genetic causes of systemic lupus erythematosus under the mentorship of Dr. Laurence Morel. From his graduate research he developed a special interest in the influence of T cell metabolism in skewing from normal immune function to autoimmunity. His work in the Brusko Lab continues to center on this aspect of T cell metabolism and how it can be manipulated to ameliorate type I diabetes. In addition, he has received EPIG funding to study how augmentation of T cell receptor-signaling and cytokine-signaling can improve regulatory T cell therapy.
Yiming Yin, Seung-Chul Choi, Zhiwei Xu, Daniel J. Perry, Howard R. Seay, Byron P. Croker, Eric S. Sobel, Todd M. Brusko and Laurence Morel. “Normalization of CD4+ T cell metabolism reverses lupus” Science Translational Medicine. 2015 Feb 11;7(274):274ra18. doi: 10.1126/scitranslmed.aaa0835. PMID: 25673763
Thompson JA, Perry D, Brusko TM. Autologous Regulatory T Cells for the Treatment of Type 1 Diabetes. Curr Diab Rep. 2012 Jul 28. PubMed PMID: 22843491.
Perry DJ, Yin Y, Telarico T, Baker HV, Dozmorov I, Perl A, Morel L. Murine lupus susceptibility locus Sle1c2 mediates CD4+ T cell activation and maps to estrogen-related receptor γ. J Immunol. 2012 Jul 15;189(2):793-803. Epub 2012 Jun 18. PMID: 22711888
Perry D, Peck AB, Carcamo WC, Morel L, Nguyen CQ. The current concept of T (h) 17 cells and their expanding role in systemic lupus erythematosus. Arthritis. 2011;2011:810649. Epub 2011 Mar 22.
Xu Z, Potula HH, Vallurupalli A, Perry D, Baker H, Croker BP, Dozmorov I, Morel L. Cyclin-dependent kinase inhibitor Cdkn2c regulates B cell homeostasis and function in the NZM2410-derived murine lupus susceptibility locus Sle2c1. J Immunol. 2011 Jun 15;186(12):6673-82. Epub 2011 May 4. PubMed PMID: 21543644.
Perry D, Sang A, Yin Y, Zheng YY, Morel L. Murine models of systemic lupus erythematosus. J Biomed Biotechnol. 2011;2011:271694. Epub 2011 Feb 14. Review. PubMed PMID: 21403825; PubMed Central PMCID: PMC3042628.
Rahman ZS, Niu H, Perry D, Wakeland E, Manser T, Morel L. Expression of the autoimmune Fcgr2b NZW allele fails to be upregulated in germinal center B cells and is associated with increased IgG production. Genes Immun. 2007 Oct;8(7):604-12. Epub 2007 Aug 23. PubMed PMID: 17713556.
Chen Y, Perry D, Boackle SA, Sobel ES, Molina H, Croker BP, Morel L. Several genes contribute to the production of autoreactive B and T cells in the murine lupus susceptibility locus Sle1c. J Immunol. 2005 Jul 15;175(2):1080-9. PubMed PMID: 16002709.
Lab: (352) 273-9300